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From First Principles From First Principles Krishna Choudhary and Lester Nare Science Meets Vedanta Science Meets Vedanta Jayant Kapatker ReddX Reddit Reads ReddX Reddit Reads ReddX My Weird Prompts My Weird Prompts Daniel Rosehill Healthcare NOW Radio Podcast Network - Discussions on healthcare including technology, innovation, policy, data security, telehealth and more. Visit HealthcareNOWRadio.com Healthcare NOW Radio Podcast Network - Discussions on healthcare including technology, innovation, policy, data security, telehealth and more. Visit HealthcareNOWRadio.com Healthcare NOW Radio and Podcast Network - Radio and Podcasts for the Healthcare Industry FM4 Science Busters FM4 Science Busters ORF Radio FM4 Vedanta Cast Vedanta Cast Jonas Masetti Soif de Sens | Écologie & social Soif de Sens | Écologie & social Pierre Chevelle | Écologie Maintenant Vous Savez Santé Maintenant Vous Savez Santé Bababam London Weather Daily London Weather Daily Fast Foundations Talking Rubbish - Recycled Content Talking Rubbish - Recycled Content James Piper, Robbie Staniforth The Secret Teachings The Secret Teachings Ryan Gable Trent Loos Podcast Trent Loos Podcast Trent Loos Water Colors Aquarium Gallery Water Colors Aquarium Gallery Water Colors Aquarium Gallery La Mano Peluda La Mano Peluda Radio Fórmula ZEIT Geschichte. Wie war das noch mal? ZEIT Geschichte. Wie war das noch mal? DIE ZEIT This Week in Virology This Week in Virology Vincent Racaniello Exploring Humanity Through Sci-Fi Exploring Humanity Through Sci-Fi Tony Tellado Two Rabbits One Hole Two Rabbits One Hole Michael and Tracie McGuire, Mike McGuire, Garrett Ballard El colegio invisible El colegio invisible OndaCero Багатий внутрішній світ Багатий внутрішній світ Євген Пілецький et al. On This Day in Working Class History On This Day in Working Class History Working Class History JP Lovecraft's Creepy Podcast JP Lovecraft's Creepy Podcast JP Lovecraft Breeders Syndicate 3.0 Breeders Syndicate 3.0 Matthew Riot IQ - Wissenschaft und Forschung IQ - Wissenschaft und Forschung Bayerischer Rundfunk c’t uplink - der IT-Podcast aus Nerdistan c’t uplink - der IT-Podcast aus Nerdistan c’t Magazin Authentic Biochemistry Authentic Biochemistry Dr Daniel J. Guerra The Grave Talks | Haunted, Paranormal & Supernatural The Grave Talks | Haunted, Paranormal & Supernatural Ghost Stores, Haunted, Paranormal & Supernatural Stories Fun Kids Science Quest Fun Kids Science Quest Fun Kids More or Less More or Less BBC Radio 4 Real Ghost Stories Online Real Ghost Stories Online Real Ghost Stories Online | Paranormal, Supernatural & Horror Radio Veterinary Vertex Veterinary Vertex AVMA Journals Movers and Shakers: a podcast about life with Parkinson's Movers and Shakers: a podcast about life with Parkinson's Podot The Mercy of Pods The Mercy of Pods Brigid & Clint Merschman Seeds Cup of Joe Merschman Seeds Cup of Joe Merschman Seeds Farming Today Farming Today BBC Radio 4 Τα podcasts του Newshub.gr Τα podcasts του Newshub.gr newshub.gr
From First Principles

Science

From First Principles

Krishna Choudhary and Lester Nare

New Rules For Heredity (Non-Mendelian Inheritance of Epigenetics) (EP 44)

June 26, 2026 3:02pm 1:37

Hosted by Lester Nare and Krishna Choudhary, this episode marks Krishna’s return to the studio after paternity leave — and the timing could not be more fitting. Today’s deep dive is about inheritance: not just the classi...

Dr. Michael Blanton on Open Data, Galaxy Surveys, and the Future of Astronomy (EP 43)

June 04, 2026 5:33pm 43 min

Hosted by Lester Nare and Krishna Choudhary, this episode is the second interview in our ongoing collaboration series with Carnegie Observatories. Krishna sits down with Dr. Michael Blanton, the new Director of the Carne...

How Scientists Actually Study Dark Matter (EP 42)

May 21, 2026 11:00am 1:06

Hosted by Lester Nare, this episode features astrophysicist Dan Gilman for a deep conversation on one of the biggest open questions in modern physics: what dark matter actually is. Starting from first principles, Lester ...

Dr. John Mulchaey on Carnegie Science and the Future of Astronomy (EP 41)

May 13, 2026 11:32am 37 min

Hosted by Lester Nare and Krishna Choudhary, this interview features John Mulchaey, the 12th President of Carnegie Science and former Director of the Carnegie Observatories. The conversation starts with his early work on...

Ant Scans, Lunar Chickpeas, Hidden Galaxies & Superconductivity (EP 40)

April 29, 2026 3:25pm 36 min

Hosted by Lester Nare and Krishna Choudhary, this rundown episode covers four new science stories at a high level: a huge new 3D ant imaging database built with synchrotron X-ray microtomography, a lunar agriculture expe...

The Prometheus Constellation: Dramaturgical and Scientific Analysis of the Physicists in Oppenheimer (EP 39)

April 21, 2026 10:56am 1:37

Hosted by Lester Nare and Krishna Choudhary, this special episode ranks the 26 scientists shown in Christopher Nolan’s Oppenheimer by one standard only: their contribution to fundamental science. Starting with the Manhat...

Harder Than Diamond? The New Hexagonal Diamond Breakthrough (EP 38)

April 15, 2026 3:33pm 57 min

Hosted by Lester Nare and Krishna Choudhary, this episode is a deep dive into one of the strangest and most hard-fought materials science stories in decades: the claim that researchers have finally synthesized bulk hexag...

Artemis II: Deep Dive on the Moon Flyby, Earthset, and Reentry (EP 37)

April 09, 2026 9:34am 1:25

Hosted by Lester Nare and Krishna Choudhary, this episode is a full deep dive on Artemis II as the crew returns from humanity’s first crewed lunar flyby in more than 50 years. Lester and Krishna break down the mission ph...

Artemis II, Claude Code Leak, iPhone Spyware & Project Hail Mary (EP 36)

April 03, 2026 11:00am 1:01

Hosted by Lester Nare and Krishna Choudhary, this rundown episode covers five new science and tech stories at a high level: NASA’s Artemis 2 moon mission, what actually leaked in the Claude Code incident, a new cancer ge...

Can AI Help Wake Coma Patients? The Science of Consciousness (EP 35)

March 31, 2026 10:00am 1:08

Hosted by Lester Nare and Krishna Choudhary, this episode is a deep dive into one of the hardest questions in neuroscience: what breaks in the brain during a coma, and can we figure out how to turn consciousness back on?...

AI Cancer Vaccines, Strange Fish, Ketamine, and Ancient Life (EP. 34)

March 27, 2026 3:03pm 44 min

Hosted by Lester Nare and Krishna Choudhary, this episode is a fast-moving science rundown covering four remarkable stories from across AI, genetics, neuroscience, and paleontology. We dig into the story of a machine lea...

Can Human Neurons Really Play Doom? The Science Behind Wetware (EP. 33)

March 24, 2026 9:19am 1:13

Hosted by Lester Nare and Krishna Choudhary, this episode is a deep dive into one of the strangest science stories of the year: a dish of human neurons allegedly learning to play Doom. We go back to the original 2022 Dis...

5,000-Year-Old Bacteria, Solar Storms, Dogs, and Meta’s AI War (EP. 32)

March 20, 2026 9:00am 38 min

Hosted by Lester Nare and Krishna Choudhary, this is our first standalone rundown episode — a faster, looser format where we hit several stories we didn’t have room to turn into full deep dives. This week: bacteria reviv...

Optovolution: Teaching Proteins to Think Like Computers (EP. 31)

March 18, 2026 11:00am 55 min

Hosted by Lester Nare and Krishna Choudhary, this episode is a deep dive into a new synthetic-biology breakthrough out of EPFL: OptoEvolution. The big idea is simple but powerful — traditional directed evolution is great...

Can We Stop an Asteroid? The Physics Behind NASA’s DART Mission (EP. 30)

March 16, 2026 11:00am 54 min

Hosted by Lester Nare and Krishna Choudhary, this episode is a full deep dive on planetary defense. We break down NASA’s DART mission, why the goal was never to “blow up” an asteroid but to gently nudge it, and why the n...

Astrobiology’s Biggest Survival Test + A Vaccine Against Everything? (EP. 29)

March 12, 2026 5:32am 2:04

Hosted by Lester Nare and Krishna Choudhary, this episode starts in astrobiology with a fresh experimental challenge to one of the biggest objections to lithopanspermia: can life actually survive the violence of being bl...

Dark Galaxies, Fuzzy Dark Matter, and an Alzheimer’s Breakthrough (EP. 28)

March 04, 2026 10:04am 1:51

Hosted by Lester Nare and Krishna Choudhary, this episode has two main stories: an astrophysics update on a candidate “dark galaxy” in the Perseus Cluster (a halo that’s ~99.9% dark matter), and a major Alzheimer’s mecha...

Dream Engineering, the Proton Radius Puzzle, and an ALS Breakthrough (EP. 27)

February 26, 2026 5:00am 2:12

Hosted by Lester Nare and Krishna Choudhary, this episode has three main stories: interactive dream engineering (yes, two-way “communication” during lucid dreaming), the proton radius puzzle finally getting resolved by a...

Winter Olympics Deep Dive: Ice Physics, Performance Pressure, and Climate Change (EP. 26)

February 18, 2026 8:00am 1:50

Hosted by Lester Nare and Krishna Choudhary, this episode is a Winter Olympics deep dive from first principles—physics, neuroscience, and climate science in one ride.• Why ice is slippery: the “water layer” story is inco...

Plants, Quantum Sensors, and Predicting Cancer Evolution (EP. 25)

February 10, 2026 10:00am 1:49

Hosted by Lester Nare and Krishna Choudhary, this episode jumps from plant biochemistry to quantum metrology to cancer evolution. We start with a University of York breakthrough that solves a ~50-year mystery in alkaloid...

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